Treatment of kidney transplant rejection
Adult: For the treatment of corticosteroid-resistant cases: In combination with other immunosuppressive agents: 1.5 mg/kg daily for 7-14 days. Doses are given via IV infusion, using a 0.22 µmeter in-line filter; administer the 1st dose over at least 6 hours and then the subsequent doses over at least 4 hours. Premedicate with corticosteroids, antihistamines, and/or antipyretics 1 hour before administration. Dose interruption or discontinuation may be required according to individual safety or tolerability; dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: Same as adult dose.
Child: Same as adult dose.
Intravenous
Prophylaxis of rejection in kidney graft transplant
Adult: In combination with other immunosuppressive agents: 1-1.5 mg/kg daily for 3-9 days. Alternatively, 1.5 mg/kg daily for 4-7 days. Doses are given via IV infusion, using a 0.22 µmeter in-line filter; administer the 1st dose over at least 6 hours and then the subsequent doses over at least 4 hours. Premedicate with corticosteroids, antihistamines, and/or antipyretics 1 hour before administration. Dose interruption or discontinuation may be required according to individual safety or tolerability; dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: Same as adult dose.
Child: Same as adult dose.
Intravenous
Prophylaxis of rejection in cardiac graft transplant
Adult: In combination with other immunosuppressive agents: 1-2.5 mg/kg daily for 3-5 days. Doses are given via IV infusion, using a 0.22 µmeter in-line filter; administer the 1st dose over at least 6 hours and then the subsequent doses over at least 4 hours. Premedicate with corticosteroids, antihistamines, and/or antipyretics 1 hour before administration. Dose interruption or discontinuation may be required according to individual safety or tolerability; dosage and treatment recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: Same as adult dose.
Child: Same as adult dose.